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KMID : 0928520110210020061
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Korean Journal of Lipidology
2011 Volume.21 No. 2 p.61 ~ p.66
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Barnidipine and Efonidipine Improve Endothelial Function in Patients with Hypertension
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Park Yae-Min
Choi Ha-Nul
Koh Kwang-Kon
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Abstract
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Background: Calcium channel blockers (CCBs) activate nitric oxide (NO) synthase in vitro and enhance NO production in vivo. We hypothesized that barnidipine therapy may improve endothelial dysfunction in patients with hypertension like efonidipine.
Methods: Twenty-five hypertensive patients were considered eligible for this study. Participants were randomly assigned to either efonidipine 40 to 80 mg or barnidipine 10 mg to 15 mg daily during 8 weeks. Patients were then crossed-over to the second treatment arm upon completion of the first treatment arm.
Results: Nineteen patients (mean age: 49 years) finished the whole study. When compared with baseline, barnidipine and efonidipine therapies significantly reduced systolic and diastolic blood pressure, respectively (both P<0.001 by ANOVA). With regard to lipoprotein levels, when compared with baseline, barnidipine and efonidipine therapies did not significantly change lipoprotein levels. However, when compared with baseline, barnidipine significantly improved flow-mediated dilator response to hyperemia by 72.2±11.7% (P<0.001) and efonidipine by 62.6±8.4% (P<0.001), respectively. With regard to insulin and glucose levels, when compared with baseline, barnidipine and efonidipine therapies did not significantly change. Also, when compared with baseline, barnidipine and efonidipine therapies did not significantly change insulin sensitivity assessed by QUICKI.
Conclusions: Barnidipine and efonidipine therapies improved endothelial function assessed by flow-mediated dilation in patients with hypertension without improving insulin sensitivity.
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KEYWORD
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Calcium channel blockers, Endothelial function, Flow-mediated dilation, Hypertension
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